Recombinant Human Soluble VEGFR1 / FLT1

Molecule:

VEGFR1/FLT1

Synonyms:

FLT1, FLT, vascular endothelial growth factor receptor 1, fms-like tyrosine kinase 1, FLT-1

Species:

Human

Cat. No.:

CRF103A pdf (datasheet)

Quantity/Size:

5 μg

Price:

$265.00 BUY

Description:

VEGFR1/FLT1 is a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. VEGFR1 binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of VEGFR1 is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Compared to VEGFR-2 the VEGFR1 receptor has a higher affinity for VEGF but a weaker signaling activity. VEGFR1 thus leads not to proliferation of endothelial cells, but mediates signals for differentiation. Recombinant human soluble VEGFR1 (sVEGFR1) is a glycosylated single polypeptide chain consisting of the first 6 extracellular domains (Met1-His688), containing 661 amino acids, including the unique 31 amino acids residues at the C-terminus.

Entrez Symbol:

FLT1

Uniprot Name:

Vascular endothelial growth factor receptor 1

Uniprot ID:

P17948-2

Data PDF:

CRF103

Source:

Insect cells

Molecular Weight:

96 kDa

Formulation:

Lyophilized from a solution in PBS.

Purity:

>95% by SDS-PAGE, visualized by silver stain

Biological Activity:

The activity of sVEGFR-1 was determined by its ability to inhibit the VEGF-A induced proliferation of HUVECs.

Amino Acid Sequence:

SKLKDPELSL KGTQHIMQAG QTLHLQCRGE AAHKWSLPEM VSKESERLSI TKSACGRNGK QFCSTLTLNT AQANHTGFYS CKYLAVPTSK KKETESAIYI FISDTGRPFV EMYSEIPEII HMTEGRELVI PCRVTSPNIT VTLKKFPLDT LIPDGKRIIW DSRKGFIISN ATYKEIGLLT CEATVNGHLY KTNYLTHRQT NTIIDVQIST PRPVKLLRGH TLVLNCTATT PLNTRVQMTW SYPDEKNKRA SVRRRIDQSN SHANIFYSVL TIDKMQNKDK GLYTCRVRSG PSFKSVNTSV HIYDKAFITV KHRKQQVLET VAGKRSYRLS MKVKAFPSPE VVWLKDGLPA TEKSARYLTR GYSLIIKDVT EEDAGNYTIL LSIKQSNVFK NLTATLIVNV KPQIYEKAVS SFPDPALYPL GSRQILTCTA YGIPQPTIKW FWHPCNHNHS EARCDFCSNN EESFILDADS NMGNRIESIT QRMAIIEGKN KMASTLVVAD SRISGIYICI ASNKVGTVGR NISFYITDVP NGFHVNLEKM PTEGEDLKLS CTVNKFLYRD VTWILLRTVN NRTMHYSISK QKMAITKEHS ITLNLTIMNV SLQDSGTYAC RARNVYTGEE ILQKKEITIR GEHCNKKAVF SRISKFKSTR NDCTTQSNVK H

Storage/Stability:

Upon receipt store at -20 °C to -80 °C.