Recombinant Rat Growth Hormone

Synonyms:

GH, met-rGH, Somatotrophin, Gh1

Species:

Rat

Cat. No.:

GHCM001 pdf (datasheet)

Quantity/Size:

1 mg

Price:

$990.00 BUY

Description:

Growth hormone (GH) is a single-chain polypeptide hormone which is synthesized, stored and secreted by the somatotroph cells of the anterior pituitary gland. It stimulates growth, cell division and regeneration and controls metabolism both directly and through the generation of IGF-I. For example, GH acts by interacting with specific receptors on the cell surface where it activates the MAPK/ERK pathway and directly stimulates division and multiplication of chondrocytes. GH also activates the JAK-STAT signalling pathway and the production of IGF-I. The liver is a major target organ and along with adipocytes, is the principal site of IGF-I production which mediates some of the effects of GH.

Methionyl growth hormone is identical to the pituitary hormone in all aspects. Recombinant expression in in E. coli is unable to remove the N-terminal methionine residue to start instruction for translation.

Entrez Symbol:

Gh1

Uniprot Name:

Somatotrophin

Uniprot ID:

P01244

Data PDF:

GHCU100

Source:

E. coli

Molecular Weight:

21.94 kDa (191 aa)

Physical State:

Lyophilized

Formulation:

10 mM sodium phosphate, pH 8.8, containing met-rGH:mannitol:glycine (1:5:1 w/w)

Purity:

97%, monomer, as determined by gel filtration chromatography (SEC)

Endotoxin Level:

< 0.1 EU/µg

Storage/Stability:

Stable as supplied for 1 year at 2-8°C.