Recombinant Human/Mouse/Rat Activin A Animal Free

Synonyms:

Inhibin beta-1, FRP, FSH-releasing protein

Species:

Mouse | Human

Cat. No.:

CS359C-AF pdf (datasheet)

Quantity/Size:

1 mg

Price:

$3,870.00 / Special Price: $2,980.00 BUY

Description:

Activin A is a member of the TGFbeta family of proteins produced by many cell types throughout development. Activins interact with Type I and Type II serine/threonine kinases to signal to SMAD proteins to regulate a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, metabolism, etc. Activin A is a homodimer of two beta A chains and is not biologically active until the N terminal propeptide is cleaved from each. Human, mouse, rat, porcine, bovine and feline Activin A have 100% amino acid sequence identity. Activin A is a non-glycosylated homodimer, containing two 117 amino acid chains.

Manufactured without Animal-derived products, in an Animal Free facility.

Uniprot ID:

P08476

Data PDF:

CS359-AF

Source:

E. coli

Molecular Weight:

Dimer, 13.1/26.2 kDa

Physical State:

Lyophilized

Formulation:

Sterile filtered, lyophilized aqueous solution containing 0.1% TFA.

Purity:

> 95% determine reducing and non-reducing SDS-PAGE.

Biological Activity:

ED50 ≤10 ng/ml, determined by the ability to induce cytoxicity MPC-11 cells.

Specific Activity:

> 1.0 x 105 units/mg The specific activity of Human/Mouse/Rat Activin A is approximately 1.2 IU/μg, which is calibrated against recombinant human Activin A WHO International Standard (NIBSC code: 91/626).

Endotoxin Level:

≤1 EUs/μg, determined by kinetic LAL analysis.

Amino Acid Sequence:

MGLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS

Storage/Stability:

Stable as supplied for 1 year at -20°C to -80°C

Application notes:

Manufactured without Animal-derived products, in an Animal Free facility.