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Recombinant Mouse CXCL16

Molecule:

CXCL16

Synonyms:

CXCLG16, SCYB16, SR-PSOX

Species:

Mouse

Cat. No.:

CRC950C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$2,700.00 / Special Price: $1,750.00 BUY

Description:

Recombinant mouse CXCL16 is a single non-glycosylated polypeptide chain containing 88 amino acids.

Background: CXCL16 (CXC chemokine 16) is a nonELR motifcontaining CXC chemokine with a transmembrane domain. CX3CL1/Fractalkine and CXCL16 are the only two transmembrane chemokines within the superfamily. Mouse CXCL16 cDNA encodes a 246 amino acid residues (a.a.) precursor protein with a putative 26 a.a. residues signal peptide,an 88 a.a. residues chemokine domain, an 87 a.a. residues mucin like spacer region, a 22 a.a. residue trans-membrane domain, and a 23 a.a. residues cytoplasmic tail. Mouse and human CXCL16 share 49% overall a.a. identity and 70% similarity in the chemokine domains. Mouse CXCL16 is produced by dendritic cells in lymphoid organ T cell zones and by cells in the splenic red pulp both as membranebound and soluble forms. Based on northern blot analysis, CXCL16 is also expressed in some nonlymphoid tissues such as lung, small intestine and kidney. The receptor for CXCL16 has been identified as CXCR6/Bonzo (STRL33 and TYMSTR), a receptor previously shown to be a co-receptor for HIV entry.CXCR6 is expressed on naive CD8 cells, natural killer T cells and activated CD8 and CD4 T cells.

Entrez Symbol:

CXCL16

Data PDF:

CRC950

Source:

E. coli

Molecular Weight:

~9.9 kDa

Formulation:

Lyophilized from a 0.2 μm filtered concentrated solution in PBS.

Purity:

>98% by SDS-PAGE and HPLC analyses.

Biological Activity:

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using murine lymphocytes is in a concentration of 20-1000 ng/ml.

Endotoxin Level:

Less than 1 EU/μg of rMuCXCL16 as determined by LAL method.

Amino Acid Sequence:

NQGSVAGSCS CDRTISSGTQ IPQGTLDHIR KYLKAFHRCP FFIRFQLQSK SVCGGSQDQW VRELVDCFER KECGTGHGKS FHHQKHLP

Reconstitution:

Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/ml. Further dilutions should be made in appropriate buffered solutions.

Storage/Stability:

This lyophilized preparation is stable at 2-4°C, but should be kept desiccated at -20°C for long term storage. Upon reconstitution, the preparation is stable for up to one week at 2-4°C.