Synonyms:
GDNF, astrocyte-derived trophic factor, ATF1, ATF2, HSCR3, HFB1-GDNF
Description:
Glial Cell Line-Derived Neurotrophic Factor (GDNF) is a neurotrophic factor that is closely related to other neurotrophic factors, such as Neurturin, Persephin, and Artemin, by a common structural feature called the cysteine-knot. GDNF signals through a multicomponent system of receptors that includes RET and GFRα1-4, to promote dopamine uptake, survival and differentiation of neurons.
Molecular Weight:
Dimer, 15.1/30.2 kDa (135/270 aa)
Physical State:
Lyophilized
Formulation:
Sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Purity:
≥95% as determined by reducing and non-reducing SDS-PAGE
Endotoxin Level:
≤1 EU/μg, by kinetic LAL
Amino Acid Sequence:
MSPDKQAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI
Storage/Stability:
Store as supplied at -20°C to -80°C.
