IFN-gamma

IFN-g, Interferon-gamma, IFN-γ

Mouse

CRI001C-AF pdf (datasheet)

1 mg

$1,120.00 / Special Price: $950.00 BUY

Interferon gamma (IFN-g) is a soluble cytokine and a type II interferon. IFN-g is secreted by innate and adaptive immune cells. The active protein is a homodimer that binds to the IFN-g receptor, which triggers a cellular response to viral and microbial infections. IFN-g exerts antiproliferative, immunoregulatory and proinflammatory activities and induces the production of cytokines, upregulates the expression of class I and II MHC antigens, Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching and potentiates the secretion of immunoglobulins by B cells. Additionally, IFN-g augments TH1 cell expansion and may be required for TH1 cell differentiation.

Made without animal-derived components in an animal-free facility.

CRI001-AF

E. coli

15.7 kDa (134 aa), monomer

Lyophilized from a sterile-filtered aqueous solution containing 10 mM sodium phosphate, 50 mM sodium chloride, pH 7.5

> 95% by reducing and non-reducing SDS-PAGE

Viral CPE assay using EMC virus on L929 cells.

≥1 x 10⁷ U/mg

≤1 EU/µg of protein by kinetic LAL analysis.

Store as supplied at -20°C to -80°C for up to 1 year. Upon reconstitution, prepare working aliquots and store at -20°C to -80°C. It is recommended that a carrier protein such as 0.1% HSA or BSA is added for long term storage. Avoid repeated freeze-thaw cycles.