Recombinant Mouse IGF-1

Molecule:

IGF 1

Synonyms:

Somatamedin C, mechano growth factor, IGF-IA

Species:

Mouse

Cat. No.:

CRI501B pdf (datasheet)

Quantity/Size:

50 μg

Price:

$235.00 BUY

Description:

Insulin-like Growth Factor I, IGF-I, is a growth factor produced in response to growth hormone-stimulated liver and can be found circulating throughout the body and throughout life. IGF-I activates the IGF-I receptor (IGF1R) and the insulin receptor to mediate growth of almost every cell of the body. IGF-I is known as one of the most potent activators of the AKT signaling pathway which is known to be a stimulator of proliferation and an inhibitor of programmed cell death. Mature human IGF-I is 100% homologous with bovine and porcine proteins.

Entrez Symbol:

Igf1

Uniprot Name:

Insulin-like growth factor I

Uniprot ID:

Q8CAR0

Source:

E. coli

Molecular Weight:

7.7 kDa (70 aa)

Physical State:

Lyophilized

Formulation:

Sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Purity:

≥ 95% by reducing and non-reducing SDS-PAGE

Biological Activity:

ED50 < 20 ng/ml, determined by the dose-dependent proliferation of FDC-P1 cells.

Specific Activity:

5.0 x 10e4 U/mg

Endotoxin Level:

≤ 1 EU/μg, by kinetic LAL

Amino Acid Sequence:

GPETLCGAEL VDALQFVCGP RGFYFNKPTG YGSSIRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPTKAA

Reconstitution:

Centrifuge vial prior to opening. Reconstitute in sterile ddH2O to a concentration of ?0.1 mg/ml. The solution can then be further diluted in other aqueous buffers.

Storage/Stability:

Store as supplied at -20°C to -80°C.