Recombinant Mouse Interleukin-11

Molecule:

IL-11

Synonyms:

Recombinant Mouse Interleukin-11, IL-11

Species:

Mouse

Cat. No.:

CSI20127C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$4,820.00 / Special Price: $3,720.00 BUY

Description:

Interleukin 11 (IL-11) is a member of the gp130 family of cytokines. IL-11 functions to promote hematopoietic stem cell proliferation and megakaryocyte differentiation. In nonhematopoietic cell populations, IL-11 stimulates acute-phase proteins, modulates the development of immunoglobulin-producing B cells, and regulates bone turnover. IL-11 binds the IL-11Rα receptor to activate JAK downstream signaling.

Entrez Symbol:

Il11

Uniprot ID:

P47873

Data PDF:

CSI20127

Source:

E. coli

Molecular Weight:

19.3 kDa (179 aa) monomer

Formulation:

Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Purity:

>95% by reducing and non-reducing SDS-PAGE

Biological Activity:

ED50 ≤ 250 ng/ml, determined by the dose-dependant stimulation of the proliferation of mouse B9 cells. ED50

Specific Activity:

≥ 4.0 x 10e3 units/mg

Endotoxin Level:

≤ 1 EU/µg by kinetic LAL analysis

Amino Acid Sequence:

MPGPPAGSPR VSSDPRADLD SAVLLTRSLL ADTRQLAAQM RDKFPADGDH SLDSLPTLAM SAGTLGSLQL PGVLTRLRVD LMSYLRHVQW LRRAGGPSLK TLEPELGALQ ARLERLLRRL QLLMSRLALP QAAPDQPVIP LGPPASAWGS IRAAHAILGG LHLTLDWAVR GLLLLKTRL

Reconstitution:

Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/mL. Further dilutions should be made in appropriate buffered solutions.

Storage/Stability:

Lyophilized product is stable at room temperature for shipping purposes. Upon receipt, store at -20°C to -80°C for up to 1 year.