Recombinant Mouse IL-17A

Molecule:

IL-17A

Synonyms:

IL-17, CTLA-8

Species:

Mouse

Cat. No.:

CS318C pdf (datasheet)

Quantity/Size:

1 mg

Price:

$2,720.00 / Special Price: $2,100.00 BUY

Description:

Interleukin-17A (IL-17A), also known as CTLA-8, is a pro-inflammatory cytokine member of a six-species family of proteins (IL-17A-17F). IL-17A is secreted mainly by activated CD4+ and CD8+ T lymphocytes and acts through its receptor, IL-17R, to induce the expression of many mediators of inflammation, most importantly, those that are involved in the proliferation, maturation and chemotaxis of neutrophils. Elevated levels of IL-17A have been associated with several conditions, including rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer and multiple sclerosis. Human, mouse and rat IL-17A show activity on mouse cells. Recombinant mouse IL-17A is a non-glycosylated, disulfide-linked homodimer, containing two 134 amino acid chains.

Uniprot ID:

Q62386

Data PDF:

CS318

Source:

E. coli

Molecular Weight:

Dimer, predicted MW 15.1/30.2 kDa (134/268 aa)

Formulation:

Lyophilized from a sterile filtered aqueous solution containing 0.1% trifluoroacteic acid

Purity:

≥ 95%, determined by reducing and non-reducing SDS-PAGE

Biological Activity:

ED50 ≤ 5 ng/ml, determined by the dose-dependent induction of IL-6 production in cultured mouse NIH 3T3 fibroblasts.

Specific Activity:

≥ 2.0 x 10e5 units/mg

Endotoxin Level:

≤ 1 EU/μg, by kinetic LAL analysis

Amino Acid Sequence:

MAAIIPQSSA CPNTEAKDFL QNVKVNLKVF NSLGAKVSSR RPSDYLNRST SPWTLHRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPESCPF TFRVEKMLVG VGCTCVASIV RQAA

Storage/Stability:

Lyophilized product is stable for a few weeks at 2-8°C, and at -20°C for 1 year.