Recombinant Mouse IL-17AF heterodimer

Synonyms:

Recombinant Mouse IL-17AF Heterodimer, Il17a/Il17f

Species:

Mouse

Cat. No.:

CS320C pdf (datasheet)

Quantity/Size:

1 mg

Price:

$4,820.00 / Special Price: $3,720.00 BUY

Description:

Interleukin-17AF (IL-17AF) is a member of the IL-17 family of proteins produced by a subset of T cells, called Th17, following stimulation with IL-23. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (By similarity). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover. Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (By similarity). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation In regard to these functions, IL-17AF has less activity than the IL-17A homodimer but, greater activity than the IL-17F homodimer. Human and rat IL-17AF both show activity on mouse cells. Recombinant mouse IL-17AF is a non-glycosylated, disulfide-linked heterodimer. It is containing one IL-17A subunit and one IL-17F subunit.

Entrez Symbol:

Il17a/Il17f

Uniprot ID:

Q62386, Q7TNI7

Data PDF:

CS320

Source:

E. coli

Molecular Weight:

30.1 kDa (134/286 aa) dimer

Formulation:

Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA).

Purity:

≥ 95% determined by reducing and non-reducing SDS-PAGE

Endotoxin Level:

≤ 1 EU/μg by kinetic LAL analysis

Amino Acid Sequence:

IL-17A subunit: MAAIIPQSSA CPNTEAKDFL QNVKVNLKVF NSLGAKVSSR RPSDYLNRST SPWTLHRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPESCPF TFRVEKMLVG VGCTCVASIV RQAA IL-17F subunit: MRKNPK AGVPALQKAG NCPPLEDNTV RVDIRIFNQN QGISVPREFQ NRSSSPWDYN ITRDPHRFPS EIAEAQCRHS GCINAQGQED STMNSVAIQQ EILVLRREP

Storage/Stability:

Lyophilized product is stable at room temperature for shipping purposes. Upon receipt, store at -20°C to -80°C for up to 1 year.