Recombinant Mouse Interleukin-21

Molecule:

IL-21

Species:

Mouse

Cat. No.:

CS322C pdf (datasheet)

Quantity/Size:

1 mg

Price:

$4,820.00 / Special Price: $3,720.00 BUY

Description:

Interleukin-21 (IL-21) is a member of the common gamma-chain family of cytokines (includes IL-2, IL-4, IL-7, IL-9, IL-13, and IL-15) and is expressed by activated CD4+ T cells. IL-21 has a private receptor known as IL-21R, which is expressed on T, B, and NK cells. Within the B cell lineage, IL-21 regulates IgG1 production and cooperates with IL-4 for the production of multiple Ab classes in vivo. Initial studies have demonstrated that IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, natural killer, and dendritic cells.

Entrez Symbol:

Il21

Uniprot ID:

Q9ES17

Data PDF:

CS322

Source:

E. coli

Molecular Weight:

15.1 kDa (130 aa)

Physical State:

Lyophilized

Formulation:

Sterile filtered solution containing 20 mM NaHCO3, pH 8.5.

Purity:

≥ 95% determined by reducing and non-reducing SDS-PAGE.

Biological Activity:

ED50 < 20 ng/ml, determined by a dose-dependent proliferation of B9 cells.

Specific Activity:

≥ 5.0 x 10e4 units/mg

Endotoxin Level:

≤ 1 EU/μg by kinetic LAL analysis.

Amino Acid Sequence:

MHKSSPQGPD RLLIRLRHLI DIVEQLKIYE NDLDPELLSA PQDVKGHCEH AAFACFQKAK LKPSNPGNNK TFIIDLVAQL RRRLPARRGG KKQKHIAKCP SCDSYEKRTP KEFLERLKWL LQKMIHQHLS

Storage/Stability:

Store as supplied for up to 1 year at -20°C to -80°C.