Synonyms:
IL-10-related T-cell-derived-inducible factor, ILTIF, IL-TIF, TIFa
Description:
IL-22 belongs to the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes and dendritic cells, IL-10 contributes to the inflammatory response in vivo. IL-22 signals through CRF2-4 and IL-22. Along with IL-17, it is rapidly produced by splenic LTi-like cells and can be also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive and innate immune systems. Mouse interleukin-22 has approximately 81% and 92% amino acid sequence identity with human and rat IL-22.
Molecular Weight:
Monomer, 16.8 kDa (147 aa)
Physical State:
Lyophilized
Formulation:
Sterile (0.2 micron) filtered solution containing 0.1% Trifluoroacetic Acid (TFA)
Purity:
> 95 % by reducing and non-reducing SDS-PAGE
Biological Activity:
ED50 ≤1 ng/ml, determined by dose-dependent induction of IL-10 secretion in human COLO 205 cells.
Specific Activity:
≤ 1.0 × 10e6 U/mg
Endotoxin Level:
< 1 EU/µg, by kinetic LAL method.
Amino Acid Sequence:
MLPVNTRCKL EVSNFQQPYI VNRTFMLAKE ASLADNNTDV RLIGEKLFRG VSAKDQCYLM KQVLNFTLED VLLPQSDRFQ PYMQEVVPFL TKLSNQLSSC HISGDDQNIQ KNVRRLKETV KKLGESGEIK AIGELDLLFM SLRNACV
Storage/Stability:
Store at -20°C to -80°C for up to 1 year.
