Recombinant Mouse IL-22

Molecule:

IL-22

Synonyms:

IL-10-related T-cell-derived-inducible factor, ILTIF, IL-TIF, TIFa

Species:

Mouse

Cat. No.:

CRI227C pdf (datasheet)

Quantity/Size:

1 mg

Price:

$4,820.00 / Special Price: $3,720.00 BUY

Description:

IL-22 belongs to the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes and dendritic cells, IL-10 contributes to the inflammatory response in vivo. IL-22 signals through CRF2-4 and IL-22. Along with IL-17, it is rapidly produced by splenic LTi-like cells and can be also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive and innate immune systems. Mouse interleukin-22 has approximately 81% and 92% amino acid sequence identity with human and rat IL-22.

Entrez Symbol:

Il22

Uniprot ID:

Q9JJY9

Source:

E. coli

Molecular Weight:

Monomer, 16.8 kDa (147 aa)

Physical State:

Lyophilized

Formulation:

Sterile (0.2 micron) filtered solution containing 0.1% Trifluoroacetic Acid (TFA)

Purity:

> 95 % by reducing and non-reducing SDS-PAGE

Biological Activity:

ED50 ≤1 ng/ml, determined by dose-dependent induction of IL-10 secretion in human COLO 205 cells.

Specific Activity:

≤ 1.0 × 10e6 U/mg

Endotoxin Level:

< 1 EU/µg, by kinetic LAL method.

Amino Acid Sequence:

MLPVNTRCKL EVSNFQQPYI VNRTFMLAKE ASLADNNTDV RLIGEKLFRG VSAKDQCYLM KQVLNFTLED VLLPQSDRFQ PYMQEVVPFL TKLSNQLSSC HISGDDQNIQ KNVRRLKETV KKLGESGEIK AIGELDLLFM SLRNACV

Storage/Stability:

Store at -20°C to -80°C for up to 1 year.