Recombinant Mouse IL-27/p28

Molecule:

IL-27

Synonyms:

IL-27, IL-27 p28 subunit, IL-30, p28, Interleukin-27 subunit alpha, IL-27-A

Species:

Mouse

Cat. No.:

CRI243C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$4,820.00 / Special Price: $3,720.00 BUY

Description:

The p28 subunit of IL-27 (IL-27/p28), also known as Interleukin-30 (IL-30), is a member of the IL-12 family of cytokines. When combined with EBI3 (Epstein-Barr virus induced gene 3), p28 forms a heterodimer known as IL-27, a cytokine which functions in innate immunity. p28 is thought to be a pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9.

Entrez Symbol:

Il27

Uniprot ID:

Q8K3I6

Source:

E. coli

Molecular Weight:

23.7 kDa (207 aa)

Physical State:

Lyophilized

Formulation:

Sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium bicarbonate, pH 8.5

Purity:

> 95% by reducing and non-reducing SDS-PAGE.

Biological Activity:

Biologically active, no acceptance criteria.

Endotoxin Level:

< 1 EU/ug, by kinetic LAL.

Amino Acid Sequence:

MFPTDPLSLQ ELRREFTVSL YLARKLLSEV QGYVHSFAES RLPGVNLDLL PLGYHLPNVS LTFQAWHHLS DSERLCFLAT TLRPFPAMLG GLGTQGTWTS SEREQLWAMR LDLRDLHRHL RFQVLAAGFK CSKEEEDKEE EEEEEEEEKK LPLGALGGPN QVSSQVSWPQ LLYTYQLLHS LELVLSRAVR DLLLLSLPRR PGSAWDS

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year.