Recombinant Mouse IL-3

Molecule:

IL-3

Synonyms:

interleukin-3, mast cell growth factor, mast-cell growth factor, P-cell stimulating factor, P-cell-stimulating factor, hematopoietic growth factor, multilineage-colony-stimulating factor, multipotential colony-stimulating factor

Species:

Mouse

Cat. No.:

CRI128C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$3,200.00 / Special Price: $2,100.00 BUY

Description:

Recombinant Mouse Interleukin-3 (IL3) is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is a species-specific, variably glycosylated cytokine.

Entrez Symbol:

Il3

Uniprot ID:

P01586

Data PDF:

CRI128

Source:

E. coli

Molecular Weight:

~14.8 kDa

Physical State:

Lyophilized

Formulation:

Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Purity:

> 95.0% by reducing and non-reducing SDS-PAGE

Biological Activity:

ED50 ≤250 pg/ml, as determined by the dose-dependent proliferation of murine M-NFS-60 cells.

Specific Activity:

≥ 4.0 x 10e6 units/mg

Endotoxin Level:

<1 EU/µg, by kinetic LAL.

Amino Acid Sequence:

MDTHRLTRTL NCSSIVKEII GKLPEPELKT DDEGPSLRNK SFRRVNLSKF VESQGEVDPE DRYVIKSNLQ KLNCCLPTSA NDSALPGVFI RDLDDFRKKL RFYMVHLNDL ETVLTSRPPQ PASGSVSPNR GTVEC

Reconstitution:

Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20°C. Further dilutions should be made in appropriate buffered solutions.

Storage/Stability:

Store at -20°C to -80°C for up to 1 year.