Synonyms:
Recombinant Mouse Interleukin-5, EDF, BCDFII, TRF
Description:
Interleukin-5 (IL-5) is a hematopoietic growth factor expressed in Th2, mast cells and
eosinophils. IL-5 acts through its receptor, the IL-5 receptor (IL-5R) and is involved in B
cell growth and eosinophil activation. IL-5 has been shown to be and is regulated by
GATA-3, in addition to other transcription factors. Human and mouse IL-5 are crossreactive.
Molecular Weight:
13.1/26.2 kDa (113/226 aa) dimer
Formulation:
Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, 50 mM sodium chloride, pH 7.5
Purity:
≥ 95% by reducing and non-reducing SDS-PAGE
Biological Activity:
≤ 2 ng/ml, determined by the dose-dependent proliferation of TF-1 cells.
Specific Activity:
≥ 5.0 x 10e5 units/mg
Endotoxin Level:
≤ 1 EU/μg by kinetic LAL analysis
Amino Acid Sequence:
MEIPMSTVVK ETLTQLSAHR ALLTSNETMR LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG
Storage/Stability:
Lyophilized product is stable at room temperature for shipping purposes. Upon receipt, store at -20°C to -80°C for up to 1 year.
