Recombinant Mouse Interleukin-12

Molecule:

IL-12

Synonyms:

IL-12, IL12, p40, IL12-b, IL12p40, IL-12p40 / p35, IL12a, IL-12a, IL-12p35

Species:

Mouse

Cat. No.:

CS357C pdf (datasheet)

Quantity/Size:

1 mg

Price:

$8,995.00 / Special Price: $6,080.00 BUY

Description:

Interleukin-12 (IL-12) is an important mediator of cellular-immunity produced by dendritic cells, macrophages and B cells when stimulated with antigen. IL-12 is involved in differentiating precursor helper T cells to Th1 and/or Th2 subtypes and promotes the production of IFN gamma and TNF alpha. Mouse IL-12 is active on human and mouse cells. Recombinant mouse IL-12 is a glycosylated, disulfide-linked heterodimer. It is containing one p35 subunit (193aa) and one p40 subunit (313aa), with a total of 506 amino acids.

Entrez Symbol:

Il12b/Il12a

Uniprot ID:

P43432/P43431

Molecular Weight:

predicted p35 = 21.7 kDa, p40 = 35.8 kDa, total predicted 57.5 kDa

Physical State:

Lyophilized

Formulation:

10 mM sodium phosphate, 50 mM NaCl, pH 7.5.

Purity:

> 95.0% by reducing and non-reducing SDS-PAGE

Biological Activity:

< 20 ng/ml, as determined by the induced expression of CD25 on CD8+ mouse T cells

Specific Activity:

> 5.0 x 104 units/mg

Endotoxin Level:

≤ 1 EU/μg protein, by kinetic LAL