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Macrophage Colony Stimulating Factor (M-CSF) is a hematopoietic cytokine/ growth factor produced by a wide variety of cells. M-CSF controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF acts through the CSF receptor 1.
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