Recombinant Mouse MCP1/CCL2

Molecule:

CCL2

Synonyms:

CCL2, C-C motif chemokine 2, Monocyte chemoattractant protein 1, MCP-1, Monocyte chemotactic protein 1

Species:

Mouse

Cat. No.:

CRJ000A pdf (datasheet)

Quantity/Size:

2 μg

Price:

$85.00 BUY

Description:

Monocyte Chemotactic Protein 1 is thought to be produced by injured or infected tissues. Acts as a ligand for C-C chemokine receptor CCR2 . Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. MCP-1 signals through G protein-coupled receptors, CCR2 and CCR4, to recruit memory T cells, monocytes and dendritic cells. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain.

Entrez Symbol:

Ccl2

Uniprot ID:

P10148

Source:

E. coli

Molecular Weight:

Monomer, 13.8 kDa (125 aa)

Physical State:

Lyophilized

Formulation:

Sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Purity:

> 95%, by reducing and non-reducing SDS-PAGE

Biological Activity:

ED50 ≤100 ng/ml, determined by a dose-dependent chemotaxis of human PBMCs or THP-1 cells.

Endotoxin Level:

≤ 1 EU/μg, by kinetic LAL

Amino Acid Sequence:

QPDAVNAPLT CCYSFTSKMI PMSRLESYKR ITSSRCPKEA VVFVTKLKRE VCADPKKEWV QTYIKNLDRN QMRSEPTTLF KTASALRSSA PLNVKLTRKS EANASTTFST TTSSTSVGVT SVTVN

Storage/Stability:

Store as supplied at -20°C to -80°C.