Recombinant Mouse Platelet Derived Growth Factor AA

Synonyms:

Recombinant Mouse Platelet Derived Growth Factor AA, GDGF, ODGF

Species:

Mouse

Cat. No.:

CS316C pdf (datasheet)

Quantity/Size:

1 mg

Price:

$3,520.00 / Special Price: $2,720.00 BUY

Description:

Platelet-derived growth factor (PDGF) is an important regulator of cell growth, proliferation, and angiogenesis. PDGF synthesis is induced by IL-1, IL-6, TNF-α, TGF-β and EGF signaling. PDGF functions as a mitogenic growth hormone on cells of mesenchymal lineage, such as smooth muscle and glial cells. PDGF is also stored in the alpha-granules of platelets and is released upon adherence to traumatized tissues. PDGF is a dimeric glycoprotein formed by two A chains (AA), two B chains (BB), or as a heterodimer with an A and a B chain (AB). The PDGF dimer binds the cell surface receptor tyrosine kinases PDGFR-α and PDGFR-β.

Entrez Symbol:

Pdgfa

Uniprot ID:

P20033

Data PDF:

CS316

Source:

E. coli

Molecular Weight:

14.5/29.0 kDa (126/252 aa) dimer

Formulation:

Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)

Purity:

≥ 95% determined by reducing and non-reducing SDS-PAGE

Biological Activity:

ED50 < 10 ng/ml, determined by the dose-dependent proliferation of Balb/c 3T3 cells

Endotoxin Level:

≤ 1 EU/μg by kinetic LAL analysis

Amino Acid Sequence:

MSIEEAVPAV CKTRTVIYEI PRSQVDPTSA NFLIWPPCVE VKRCTGCCNT SSVKCQPSRV HHRSVKVAKV EYVRKKPKLK EVQVRLEEHL ECACATSNLN PDHREEETGR RRESGKNRKR KRLKPT

Storage/Stability:

Lyophilized product is stable at room temperature for shipping purposes. Upon receipt, store at -20°C to -80°C for up to 1 year.