Synonyms:
Porcine IL-4, Interleukin-4, B-cell stimulatory factor-1, BSF-1, BCDF, BCGF
Description:
Interleukin 4 (IL-4) is an immunomodulatory cytokine that functions to induce naïve
helper T cells to differentiate into type 2 T helper (Th2) cells. Th2 cells subsequently
produce more IL-4 in a positive feedback loop. IL-4 also promotes immunoglobulin IgG
to IgE isotype switching on B cells. IL-4 binds the IL-4Rα receptor to activate STAT6
signaling.
Molecular Weight:
12.7 kDa (110 aa) monomer
Formulation:
Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5
Purity:
≥ 95% by reducing and non-reducing SDS-PAGE
Biological Activity:
ED50 ≤ 2 ng/ml, determined by TF-1 cell proliferation.
Specific Activity:
≥ 5.0 x 10e5 units/mg
Endotoxin Level:
≤ 1 EU/µg by kinetic LAL
Amino Acid Sequence:
MHKCDITLQE IIKTLNILTA RKNSCMELPV TDVFAAPENT TEKETFCRAS TVLRHIYRHH TCMKSLLSGL DRNLSSMANM TCSVHEAKKS TLKDFLERLK TIMKEKYSKC
Storage/Stability:
Lyophilized product is stable at room temperature for shipping purposes. Upon receipt, store at -20°C to -80°C for up to 1 year.
