Synonyms:
Recombinant Rat GDNF, Astrocyte-derived trophic factor, ATF-1
Description:
Glial cell-derived neurotrophic factor (GDNF) is a neurotrophic factor that signals through
a multicomponent receptor system to activate receptor tyrosine kinase RET signaling.
GDNF promotes dopamine uptake, prevents motor neuron apoptosis, and supports the
survival and differentiation of neurons.
Molecular Weight:
Dimer, 15.1/30.1 kDa (135/270 aa)
Formulation:
Lyophilized from a sterile-filtered solution containing 10mM sodium phosphate, pH 7.5
Purity:
≥95% by reducing and non-reducing SDS-PAGE
Biological Activity:
Typical ED50 < 0.1 µg/m, determined by dose-dependent proliferation of C6 cells.
Endotoxin Level:
≤1 EU/µg by kinetic LAL analysis
Amino Acid Sequence:
MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCEAAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDSLV YHILRKHSAK RCGCI
Storage/Stability:
Store as supplied at -20°C to -80°C for up to 1 year.
