Synonyms:
Recombinant Rat Interleukin-17A, IL-17, CTLA-8
Description:
Interleukin-17A (IL-17A), also known as CTLA-8, is a pro-inflammatory cytokine member
of a six-species family of proteins (IL-17A-17F). IL-17A is secreted mainly by activated
CD4+ and CD8+ T lymphocytes and acts through its receptor, IL-17R, to induce the
expression of many mediators of inflammation, most importantly, those that are involved
in the proliferation, maturation and chemotaxis of neutrophils. Elevated levels of IL-17A
have been associated with several conditions, including rheumatoid arthritis, airway
inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer and
multiple sclerosis. Human, mouse and rat IL-17A show activity on mouse cells.
Recombinant rat IL-17A is a non-glycosylated, disulfide-linked homodimer.
Molecular Weight:
15.1/30.3 kDa (134/268 aa) dimer
Formulation:
Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium citrate, pH 3.0
Purity:
≥ 95% determined by reducing and non-reducing SDS-PAGE
Biological Activity:
This product demonstrates dose-dependent IL-6 production in 3T3 cells detected by ELISA. Typical ED50 < 1 mg/ml.
Endotoxin Level:
≤ 1 EU/μg by kinetic LAL analysis
Amino Acid Sequence:
MAVLIPQSSV CPNAEANNFL QNVKVNLKVL NSLSSKASSR RPSDYLNRST SPWTLSRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPEKCPF TFRVEKMLVG VGCTCVSSIV RHAS
Storage/Stability:
Store at -20°C to -80°C for up to 1 year.
