Recombinant Rat IL-17A

Molecule:

IL-17A

Synonyms:

Recombinant Rat Interleukin-17A, IL-17, CTLA-8

Species:

Rat

Cat. No.:

CS323C pdf (datasheet)

Quantity/Size:

1 mg

Price:

$3,820.00 / Special Price: $2,940.00 BUY

Description:

Interleukin-17A (IL-17A), also known as CTLA-8, is a pro-inflammatory cytokine member of a six-species family of proteins (IL-17A-17F). IL-17A is secreted mainly by activated CD4+ and CD8+ T lymphocytes and acts through its receptor, IL-17R, to induce the expression of many mediators of inflammation, most importantly, those that are involved in the proliferation, maturation and chemotaxis of neutrophils. Elevated levels of IL-17A have been associated with several conditions, including rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer and multiple sclerosis. Human, mouse and rat IL-17A show activity on mouse cells. Recombinant rat IL-17A is a non-glycosylated, disulfide-linked homodimer.

Entrez Symbol:

l17a

Uniprot ID:

Q61453

Data PDF:

CS323

Source:

E. coli

Molecular Weight:

15.1/30.3 kDa (134/268 aa) dimer

Formulation:

Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium citrate, pH 3.0

Purity:

≥ 95% determined by reducing and non-reducing SDS-PAGE

Biological Activity:

This product demonstrates dose-dependent IL-6 production in 3T3 cells detected by ELISA. Typical ED50 < 1 mg/ml.

Endotoxin Level:

≤ 1 EU/μg by kinetic LAL analysis

Amino Acid Sequence:

MAVLIPQSSV CPNAEANNFL QNVKVNLKVL NSLSSKASSR RPSDYLNRST SPWTLSRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPEKCPF TFRVEKMLVG VGCTCVSSIV RHAS

Storage/Stability:

Store at -20°C to -80°C for up to 1 year.