Recombinant Rat IL-6 Animal Free

Molecule:

IL-6

Synonyms:

HGF; HSF; BSF2; IL-6; IFNB2; IL6, interleukin-6, CDF, BSF-2, IFN-beta-2, interferon beta-2, interleukin BSF-2, hybridoma growth factor, CTL differentiation factor, B cell stimulatory factor-2, B-cell stimulatory factor 2, B-cell differentiation factor

Species:

Rat

Cat. No.:

CRI150C-AF pdf (datasheet)

Quantity/Size:

1 mg

Price:

$6,260.00 / Special Price: $4,100.00 BUY

Description:

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R alpha and gp130.

Manufactured without Animal-derived products, in an Animal Free facility.

Entrez Symbol:

Il6

Uniprot ID:

P20607

Data PDF:

CRI150-AF

Source:

E. coli

Molecular Weight:

21.7 kDa (188 aa)

Physical State:

Lyophilized

Formulation:

Sterile filtered aqueous solution containing 0.1% Trifluoroacetic acid (TFA) and 5:1 mannitol to protein.

Purity:

≥ 90% by reducing and non-reducing SDS-PAGE

Biological Activity:

ED50 ≤ 2 ng/mL, as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent mouse B9 cells. ED50 ≤ 10 pg/mL, by proliferation of 7TD1 cells.

Specific Activity:

≥ 5.0 x 10e5 units/mg

Endotoxin Level:

≤1 EUs/µg by kinetic LAL

Amino Acid Sequence:

MFPTSQVRRG DFTEDTTHNR PVYTTSQVGG LITYVLREIL EMRKELCNGN SDCMNSDDAL SENNLKLPEI QRNDGCFQTG YNQEICLLKI CSGLLEFRFY LEFVKNNLQD NKKDKARVIQ SNTETLVHIF KQEIKDSYKI VLPTPTSNAL LMEKLESQKE WLRTKTIQLI LKALEEFLKV TMRSTRQT

Storage/Stability:

Stored upon receipt at -20°C to -80°C for up to 1 year.