Recombinant Rat VEGF 164

Molecule:

VEGF

Synonyms:

VEGF-A, isoform 164, VEGF164 ,VPF, glioma-derived endothelial cell mitogen

Species:

Rat

Cat. No.:

CRV102B pdf (datasheet)

Quantity/Size:

10 μg

Price:

$235.00 BUY

Description:

Vascular Endothelial Growth Factor is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intraocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase (flt 1), KDR gene product (the mouse homolog of KDR is the flk-1 gene product) and the flt4 gene product.

Uniprot ID:

P16612-2

Data PDF:

CRV102

Source:

E. coli

Molecular Weight:

38.7 kDa, disulfide-linked homodimeric protein (165 aa monomer)

Physical State:

Lyophilized

Formulation:

Lyophilized from a 0.2 µm filtered concentrated solution in 20 mM Tris, 300 mM NaCl, pH 8.8.

Purity:

> 95 % by SDS-PAGE and HPLC analyses

Biological Activity:

ED50 < 5 ng/ml, determined by proliferation of human umbilical vein endothelial cells (HUVEC).

Specific Activity:

> 2.5 × 10e5 IU/mg

Endotoxin Level:

< 1 EU/µg, by LAL analysis

Amino Acid Sequence:

MAPTTEGEQK AHEVVKFMDV YQRSYCRPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCAGC CNDEALECVP TSESNVTMQI MRIKPHQSQH IGEMSFLQHS RCECRPKKDR TKPEKHCEPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR

Storage/Stability:

Store as supplied at -20°C to -80°C