Synonyms:
VEGF-A, VPF, glioma-derived endothelial cell mitogen
Description:
Vascular endothelial growth factor-A (VEGF-A) is produced by a wide variety of cell
types, including tumor and vascular cells. VEGF-A is a mediator of vascular growth,
vascular permeability, and plays a role in stimulating vasodilation via nitric oxidedependent pathways. VEGF-A has several alternatively spliced isoforms, with VEGF-165
being the most abundant. The VEGF-165 isoform is a secreted protein that acts on
receptors VEGFR-1 and VEGFR-2 to modulate endothelial cell proliferation and
angiogenesis.
Molecular Weight:
Dimer, 19.4/38.8 kDa (165/330 aa)
Physical State:
Lyophilized
Formulation:
Lyophilized from a sterile-filtered solution containing 10 mM sodium phosphate, pH 7.5
Purity:
≥95% by reducing and non-reducing SDS-PAGE
Biological Activity:
Activity determined by HUVEC proliferation assay
Endotoxin Level:
≤1 EU/µg by kinetic LAL analysis
Amino Acid Sequence:
MAPTTEGEQK AHEVVKFMDV YQRSYCRPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCAGC CNDEALECVP TSESNVTMQI MRIKPHQSQH IGEMSFLQHS RCECRPKKDR TKPEKHCEPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR
