Recombinant Exendin-4

Synonyms:

Exenatide

Cat. No.:

CRE117A pdf (datasheet)

Quantity/Size:

20 μg

Price:

$190.00 BUY

Description:

Exendin-4 mimics the incretin hormone glucagon-like peptide 1 (GLP-1) and shares 53% sequence homology with GLP-17-36 amide. Interacts with the same membrane receptor, GLP1R, and induces hypotension that is mediated by relaxation of cardiac smooth muscle. The native hormone is found in the venom of the Gila monster (Heloderma suspectrum). Exendin-4 enhances glucose-dependent insulin secretion, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying in vivo. It also promotes β-cell proliferation and neogenesis in vitro and in animal models.

Uniprot Name:

Exendin-4

Uniprot ID:

P26349

Data PDF:

CRE117

Source:

E. coli

Molecular Weight:

~4.2 kDa (39 aa)

Physical State:

Lyophilized

Formulation:

Sterile-filtered 20 mM PBS, pH 7.0, containing 4% mannitol.

Purity:

> 96.0% as determined by SDS PAGE and HPLC analyses.

Biological Activity:

Regulates Glucose levels rapidly; Reduces Insulin resistence; Reduces Glucagon; Reduces HbA1c; Stimulates beta cell growth which stimulates insulin production.

Endotoxin Level:

< 1 EU/μg of Exendin-4 as determined by LAL method.

Amino Acid Sequence:

HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG PSSGAPPPS

Storage/Stability:

Store at -20°C to -80°C for up to 1 year.