Recombinant Rhesus Macaque IL-6

Molecule:

IL-6

Species:

Rhesus Macaque

Cat. No.:

CRI271A pdf (datasheet)

Quantity/Size:

2 μg

Price:

$190.00 BUY

Description:

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6Rα and gp130.

Entrez Symbol:

IL6

Uniprot Name:

Interleukin-6

Uniprot ID:

A0A1D5QM02

Data PDF:

CRI271

Source:

E. coli

Molecular Weight:

21.1 kDa (186 aa) monomer

Formulation:

Lyophilized from sterile-filtered PBS, pH 7.4.

Purity:

>97% by SDS-PAGE and HPLC analyses.

Biological Activity:

ED50 <0.1 ng/ml, as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent mouse 7TD1 cells.

Specific Activity:

>1×10e7 units/mg.

Endotoxin Level:

<1 EU/μg of Recombinant Rhesus Macaque Interleukin-6 as determined by LAL method

Amino Acid Sequence:

MAPVLPGEDS KNVAAPHSQP LTSSERIDKH IRYILDGISA LRKETCNRSN MCESSKEALA ENNLNLPKMA EKDGCFQSGF NEDTCLVKII TGLLEFEVYL EYLQNRFESS EEQARAVQMS TKVLIQFLQK KAKNLDAITT PEPTTNASLL TKLQAQNQWL QDMTTHLILR SFKEFLQSNL RALRQM

Storage/Stability:

Upon reconstitution , store aliquots at -80°C