Cell Sciences Introduces Purified GPCRs for Selective Drug Development

We are excited to announce the addition of a new, advanced line of G protein-coupled receptor (GPCRs) products to our online catalog.

The superfamily of G protein-coupled receptors includes over 800 receptors in the human body that participate in a wide range of physiological and pathological functions. GPCRs are some of the most successful targets in modern medicine, with 40% of marketed pharmaceuticals directed at them to modify blood pressure, allergic response, kidney function, hormonal disorders, neurological diseases, even cancer. More importantly, they represent a vast untapped therapeutic potential in medicine with more than 200 GPCRs not yet explored in clinical trials and over 120 ‘orphan’ GPCR receptors that have yet to be characterized.

With new and improved immunization-related technologies and advances in GPCR purification and expression techniques, research in this area is an exciting, expanding field that shows incredible promise for improving drug design. In fact, it is largely believed that capturing the different GPCR conformational states may be the key for the development of more selective drugs that can effectively modulate specific signaling pathways that could vastly improve therapeutic activity and minimize the undesirable side effects of drugs with these targets.

“We are extraordinarily proud to enter the GPCR research field. There are many exciting trends in GPCR drug discovery, especially in genetic and immune system disorders – we look forward to working with these innovative researchers and labs to further advance new discoveries” stated Paul Loomis, President of Cell Sciences.

We now offer receptor-enriched membrane preparations produced from highly expressing cell lines for guaranteed specific receptor binding, as well as, purified receptors.

The receptors carry a double twin-strep-tag at the N-Terminus and a 10 histidine tag at the C-Terminus allowing for affinity purification.

Shop our line of GPCR's and contact our technical support team with any questions.

You can also read our blog "Why is everyone talking about GPCR research?" to learn about the recent breakthroughs in structural biology and innovations in biotechnology that have brought GPCRs into the spotlight.