Our recent white paper “The Effects of Cytokines on T Cell Differentiation” describes how T cells are a critical component of adaptive immunity, responsible for cytokine production, direct cytotoxicity, regulation and memory, among other activities.
One mechanism by which the immune system is able to provide a defense against the wide range of pathogens and conditions affecting the body is by differentiation of this key cell type into many distinct lineages and subsets, each with a characteristic profile of effector molecules responsible for specific, sometimes overlapping functions.
This white paper explores the complex nature of the immune system and the variety of T cell lineages and subsets which arise from naïve T cells exiting the thymus. Also reviewed are the intricate combinations of antigen-stimulation and co-stimulatory molecules, cell-cell interactions and the location and cytokine milieu which all contribute to the T cell’s fate, and therefore the cell’s function in the immune system as a whole. In vitro differentiation of T cells requires high quality, active cytokines and chemokines with low endotoxin levels and high purity, which are available by searching our website.