White Paper Discusses Immune Checkpoints Major Role in Immune System Functionality

White Paper Discusses Immune Checkpoints Major Role in Immune System Functionality

We are excited to offer a whitepaper “Immune Checkpoints and the T cell” describing the importance of immune checkpoints in the regulation of the immune system’s function.

Immune checkpoints are stimulatory or inhibitory signals that play a major role in regulation of the immune system’s function. Interactions between surface molecules on immune cells lead to activation, differentiation and effector function, or inhibition of these activities. T cells, an important member of the adaptive branch of the immune system, are greatly affected by interactions between immune checkpoint molecules, including CD28 ↔ B7-1/B7-2 ↔ CTLA-4 interactions, PD-1 ↔ PD-L1/PD-L2, LAG-3 ↔ MHC, and TIM-3 ↔ galectin-9 interactions.

Proliferation, clonal expansion, differentiation into T cell subsets, and effector functions all depend on stimulation or inhibition through these surface molecules. Thus, regulation of T cells by way of blocking or stimulating the immune checkpoints can have significant effects on the function of the immune system. Recent advances in immunotherapy targeting immune checkpoint molecules have demonstrated efficacy in modulating immune reactions to self-tissues in both cancer immunity and autoimmunity. Continued research into this growing field of study is critical for advancing immunotherapeutic treatments against human diseases using immune checkpoint molecules.

We offer both recombinant human and mouse CTLA-4, PD-1, PD-L1 and PD-L2 fusion proteins. We offer two different monoclonal antibodies, with FITC- and biotin-labeling, that block human LAG-3, as well as recombinant human and mouse LAG3 fusion proteins.  Additionally, we offer recombinant human TIM-3 fusion proteins, as well as other many other immune checkpoint reagents.

Download the full whitepaper “Immune Checkpoints and the T Cell” here www.cellsciences.com/resources/whitepapers/whitepaper-immune-checkpoints-and-the-t-cell to learn more.