Synonyms:
tPA , PLAT , T-PA , TPA
Description:
Sheep Anti-human tPA polyclonal antibody. Background: This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
Immunogen:
Recombinant full length wild-type human tPA
Formulation:
Liquid in 0.05M Sodium Phosphate + 0.1M NaCl + 1mM EDTA, pH 6.6
Purification:
Affinity purified by immobilized human tPA
Storage/Stability:
After first thaw, store in working aliquots at -80οΨΑC. Avoid repeated freeze-thaw cycles.
